Vitamin B2, also known as riboflavin, is a vitamin that plays an important role in cellular energy production through its two active coenzyme forms that are involved in oxidation-reduction reactions during a variety of cellular processes. In particular it is necessary for the normal function of mitochondria, the energy factory within each human cell. Given evidence showing mitochondrial energy depletion in migraine, B2 may be effective as a nutritional support for health while living with migraine. The available studies indicate that B2 is well tolerated among adults. The dosage in the studies explored 400mg of B2 against a placebo group. Studies on the efficacy of B2 are consistent in their findings and suggest that B2 is well tolerated and efficacious.
B2 has low gut absorption. Taking B2 with food slows passage through the gut and increases absorption. Because of its low absorption characteristics, 400mg of B2 should be divided into 4 pills that can be taken once every three hours with food or two pills can be taken twice a day with food.