Butterbur is an herb native to Europe, Southwestern Asia, and North Africa. Studies have shown that its leaf and root extracts may be beneficial as a nutritional support for health while living with migraine. Petasins, the sesquiterpene compounds found in butterbur, are thought to be the active constituents. They inhibit leukotriene (a type of inflammatory molecule), cyclooxygenase and histamine activity, and are thought responsible for butterbur’s anti-inflammatory and antiallergic effects. Petasins are also known to have calcium channel- blocking effects that could help manage neurological discomfort. Studies on 75 mg of butterbur extract taken twice daily over a course of 3 months had a positive impact against placebo and performed better than the 50 mg dose taken twice daily.